Nature.com July 15, 2026 • 15:35

Modular in vivo antibody–ADC click to reverse drug resistance in tumours - Nature

Modular in vivo antibody–ADC click to reverse drug resistance in tumours - Nature

In vivo ligation of clinically used therapeutic antibodies via bioorthogonal click chemistry to antibody–drug conjugates leads to enhanced antitumour activity in heterogeneous and treatment-resistant tumours.

Ethical compliance
Animal studies were performed at the Washington University School of Medicine in compliance with institutional guidelines and protocols approved by the Institutional Animal Care a… [+35499 chars]

More from Nature.com