Nature.com May 21, 2026 • 15:32

Human inflammatory bowel disease-on-a-chip for modelling disease progression, cancer initiation and sex-specific effects - Nature

Human inflammatory bowel disease-on-a-chip for modelling disease progression, cancer initiation and sex-specific effects - Nature

Epithelial–stromal interactions drive inflammation, fibrosis, immune recruitment and cancer initiation in human IBD colon-on-a-chip devices, and responses are exacerbated by peristalsis-like movements and pregnancy-associated hormones in female-derived chips.

Establishment of human healthy and IBD colon-on-a-chip devices
Patient-specific epithelial organoids and stromal fibroblasts were isolated from surgical resections of the colon of healthy donors and… [+34050 chars]

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