Nature.com May 13, 2026 • 21:24

Long-term editing of brain circuits using an engineered electrical synapse - Nature

Connexin proteins found in white perch fish were used to engineer synthetic electrical synapses, enabling precision circuit editing in mammals.

Design of the Cx34.7 and Cx35 mutant library
A semi-rational design approach was used to design the mutant library. Sequence alignments between the M.americana connexins and the connexins for which … [+76107 chars]

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Long-term editing of brain circuits using an engineered electrical synapse - Nature

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