Prideofdetroit.com September 17, 2026 • 13:00

NFL Week 2 expert picks, score predictions: Lions at Bills - Pride Of Detroit

By Brandon Knapp

Detroit Lions vs. Buffalo Bills NFL Week 2 expert picks and score predictions by the Pride of Detroit staff. Can the Lions go on the road and pull off the upset?

The Detroit Lions hit the road for the first time in the 2026 season, traveling to Highmark Stadium to play the Buffalo Bills in their home opener at their brand-new stadium.
Obviously, really good … [+2160 chars]

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NFL Week 2 expert picks, score predictions: Lions at Bills - Pride Of Detroit

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