Fox News August 25, 2026 • 11:00

Major brain changes that occur around age 50 could impact dementia risk - Fox News

Major brain changes that occur around age 50 could impact dementia risk - Fox News

Microglia decline after age 50 as inflammatory blood-derived immune cells infiltrate the hippocampus, potentially driving neuroinflammation and dementia.

The brain may undergo a notable shift at midlife, as new research suggests that its protective immune cells begin to decline and are increasingly replaced by inflammatory cells at around age 50.
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