The HTRA2āCLPB proteostasis system is a mitochondrial quality control module whose dysfunction drives local oxygen toxicity, which can be mitigated by lowering ambient oxygen levels.
Animal use and care
Htra2 mutant mice (mnd2; strain no. 004608, background: C57BL/6J) were obtained from The Jackson Laboratory. Breeding was performed to generate homozygous mutants and correspondiā¦ [+23748 chars]
Htra2 mutant mice (mnd2; strain no. 004608, background: C57BL/6J) were obtained from The Jackson Laboratory. Breeding was performed to generate homozygous mutants and correspondiā¦ [+23748 chars]