Nature.com July 08, 2026 • 14:24

Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing - Nature

This study uses a precise and efficient clustered regularly interspaced short palindromic repeats (CRISPR) prime editing system to substitute lysine residues in histone H3, individually or in combination, identifying those essential for mouse embryonic stem c…

Adapting prime editing for mammalian histone mutagenesis
Mouse canonical histone H3 is encoded by nine H3.1 and three H3.2 genes expressed in a replication-dependent manner. The noncanonical H3.3 va… [+44240 chars]

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Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing - Nature

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